Outer retinal dysfunction in patients treated with vigabatrin
نویسندگان
چکیده
منابع مشابه
Outer retinal dysfunction in patients treated with vigabatrin.
OBJECTIVE To assess early visual impairment related to vigabatrin prospectively in patients with and without visual symptoms. BACKGROUND Vigabatrin acts as an inhibitor of gamma-aminobutyric acid (GABA) transaminase. GABA-induced ion transport changes in the retinal pigment epithelium have been described. The electro-oculogram (EOG) is a clinical test that reflects photoreceptor and pigment e...
متن کاملRetinal function abnormalities in patients treated with vigabatrin.
OBJECTIVE To evaluate central and peripheral retinal function in patients treated with vigabatrin, an antiepileptic drug associated with peripheral visual field constriction (VFC). METHODS Six patients with epilepsy treated with vigabatrin as add-on therapy for at least 3 years were included in this observational case series. All patients underwent a clinical ophthalmologic examination, color...
متن کاملVigabatrin associated retinal dysfunction in children with epilepsy.
BACKGROUND Recent reports have established that eye changes occur in patients treated with vigabatrin. AIM To identify the eye changes associated with vigabatrin, based on a prospective study of children treated for seizures. METHODS Twenty nine children on vigabatrin (mainly as add on therapy) were followed up for 6.5 years. Ophthalmic examination was performed before starting treatment an...
متن کاملVigabatrin-induced visual dysfunction in Chinese patients with refractory epilepsy.
PURPOSE Bilateral visual field constriction has been reported following the use of the antiepileptic drug (AED) vigabatrin. The incidence of retinal toxicity is variable and there are limited data in Asian populations. The authors report the results of ophthalmologic examination in Chinese patients taking this drug. METHODS The authors identified two groups of patients with refractory epileps...
متن کاملEpilepsy patients treated with vigabatrin exhibit reduced ocular blood flow.
BACKGROUND/AIM Reduced cerebral blood flow and decreased glucose metabolism have been identified in epilepsy patients receiving vigabatrin. It is likely that such a change may extend to the eye and may be linked to previously reported irreversible visual field defects. The aim of this study was to determine whether patients who have undergone anti-epileptic drug (AED) therapy with vigabatrin ha...
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ژورنال
عنوان ژورنال: Neurology
سال: 2000
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.54.6.1396